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Genome Editing Mice for Medicine (GEMM)

GEMM logo

The Mary Lyon Centre at MRC Harwell is a national facility providing world-class expertise, tools and resources to generate and characterise genetically-modified mouse models for use by clinical and biomedical scientists. It supports UK academic researchers with genome engineering, advanced phenotyping and cryopreservation. All services are underpinned by exceptional husbandry and animal care with an emphasis on refinement and reproducibility.

The MRC has committed up to £4.5m over 5 years to the Mary Lyon Centre to administer the Genome Editing Mice for Medicine (GEMM) funding scheme. This will exploit the Centre’s expertise to deliver novel mouse lines to advance knowledge of human disease and/or be of wide use in biomedical science.

The UK academic research community is invited to nominate mouse lines for production and outline their own experimental plans for them. Nominations will be assessed by a cross-discipline panel of experts across two key themes:

  1. The nominator’s own research hypotheses and specific research plans for the mouse.
  2. The beneficial impact the proposed novel mouse line will have on the wider academic community.

This award will financially support mouse line generation and archiving, but not the nominator’s own experimental research costs. Applicants will therefore be asked to describe the funding in place to support their proposed downstream work.

Successfully-generated mouse lines will be made publicly-available through the European Mouse Mutant Archive.

For full details and to submit an application, please see the Mary Lyon Centre GEMM web page.