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COVID-19 Rapid Response Rolling Call

Please note this opportunity is now CLOSED.
View all OPEN opportunities

  • Status: Closed
  • Open date: 1 Apr 2020
  • Closing date: 30 Jun 2020 16:00 GMT+1
  • Type: Grants, Researcher-led


Building on the initial calls of their Initiative, DHSC, through the NIHR, and UKRI are jointly launching a rolling call for proposals for rapid research into COVID-19.

For UK-led academic, SME and wider industry research that will address a wide range of COVID-19 knowledge gaps/needs, and which will lead to a benefit in UK, potentially international, public health within 12 months

For an up to date list of the work that is already being carried out by MRC funded researchers, please see the MRC Response to Covid-19 webpage.


The 21st Century has already seen a number of epidemics including Ebola, MERS, Zika and Nipah. Epidemics are defined by the complex interactions between microbes, people, animals and ecosystems, and factors such as increased global mobility, population density and climate change are contributing to the rise of epidemics caused by emerging and re-emerging infectious diseases.

On December 31, 2019, the WHO Office in China was informed that cases of pneumonia of an unknown cause had been detected in Wuhan City, in the Hubei Province of China. The Chinese authorities identified this to be a previously unknown type of coronavirus (SARS-CoV2, with the disease it causes being COVID-19) with subsequent phylogenetic analysis suggesting that the new virus is similar to the SARS coronavirus when compared to other coronaviruses known to infect humans. Initial cases had some link to a large seafood and animal market, suggesting animal-to-person spread, but there is now clear evidence for person-to-person spread. The outbreak was declared as a Public Health Emergency of International Concern (PHEIC) on January 30, 2020.

The research response

Research to understand the disease, prevent, treat and control it will be critical for mitigating the severity of the COVID-19 outbreak. Rapid progress in addressing this epidemic will depend upon a coherent and integrated response from researchers, industry, the healthcare system and the public. Consequently, in early February 2020 we launched a strategic Initiative encompassing two different calls i) active intervention development including vaccines and therapeutics, and ii) diagnosis and understanding of COVID-19. Over £20m was made available for this Initiative through the primary government funders of UK medical research - the Department of Health and Social Care (DHSC), through the National Institute for Health Research (NIHR), and UK Research and Innovation (UKRI), funding awards in both calls. 

Details of the first six awards to be funded through this initiative can be found here, while detail of the twenty-one studies awarded in the second round can be found here. There are also funding details about other rolling calls on this Covid-19 research and innovation supported by UKRI spreadsheet.

We are now launching a subsequent, rolling call for rapid research proposals with potential to deliver public health impacts within 12 months.

These calls are contributing to the global response by actively collaborating with and being informed by the WHO’s COVID-19 Global Research Roadmap and Global Coordinating Mechanism (GCM) for R&D in epidemics, the Global Infectious Disease Collaboration for Infectious Disease Preparedness (GloPID-R), the UK Collaborative on Development Research and the Coalition for Epidemic Preparedness Innovations (CEPI).


Short term (up to 12 month) proposals are sought that can contribute to this urgent phase of the pandemic. All proposals requiring rapid activation will need to consider the immediate morbidity and mortality associated with Covid-19 and be able to show how progress within the period of award could make a direct and significant contribution to the understanding, prevention and/or management of the UK COVID-19 outbreak. Applicants will need to consider carefully the value of linking to and building on existing investments and the need for consortia rather than localised approaches where ever appropriate.

The research scope of this call is as below:

  • Virology, Immunity and Pathophysiology - Research as part of an experimental medicine and/or clinical study focused on defining critical biological/pathological parameters necessary for the prioritisation of preventative, supportive and/or therapeutic interventions. This includes the duration of viral shedding, the immunology and immunopathology of the disease, the immunity generated post-severe, mild and asymptomatic infection and the persistence of that immunity. Population studies should ensure they include the relevant links to epidemiology or clinical expertise.
  • Diagnostics - Rapid point of care diagnostics for use at the community level in different settings. Proposals will need to robustly justify their added value, in the context of significant existing activity, and to provide strong evidence in terms of deliverability and route to commercialisation, at scale and speed.
  • Epidemiology
    • Transmission - Research that will enable better understanding of the nature of transmission of and exposure to the virus, including via surfaces and aerosols.
    • Disease Susceptibility and Severity – Understanding susceptibility of different populations (age, sex, ethnicity, demographics, occupation etc.), including vulnerable and marginalised groups, such as the homeless and drug users. Characterization of the spectrum of clinical manifestations and disease severity of SARS-CoV2 infections, including potential contribution of viral load, kinetics and genotype, sites of infection and associated immunopathology, variability in immune responses, collateral tissue damage, and associated factors (demographics, etc.).
    • Control and Mitigation – Research to understand social distancing measures that are most effective at preventing or reducing spread of SARS-CoV2, and how such distancing, shielding and isolation measures may be most effectively relaxed.
    • IPC and PPE – Studies to understand the effectiveness and optimise the use of personal protective equipment and other infection prevention and control measures in health care and community settings, including by the general public.
    • Settings – this call includes community epidemiology including in care homes and other institutional settings such as schools. prisons and homeless hostels. This call also covers social care in non-institutional contexts and domestic settings
  • Mental Health – Proposals should be focussed on the immediate needs:
    • The acute consequences of the pandemic and lockdown measures on the population and in particular the impact on suicide, self-harm and eating disorders, addiction, anxiety, depression and domestic abuse.
    • The neuropsychiatic consequences of COVID
    • The mental health outcomes associated with ICU treatment, such as depression, anxiety and post-traumatic stress
    • The immediate consequences of isolation on mental health and mental illness and the evaluation of coping strategies
    • Establishing a base line for longer term outcome studies of those infected by COVID-19, true representative population samples, and groups at particular risk (social care and health workforces, BAME, those with a pre-existing mental health issues).
    • For health and social care workers mental health, see Health and Care Delivery section.
  • Clinical Management – Rapid assessments of available data from studies to learn what standards of care are the most effective for patients at different stages of the disease, including effective triage, and taking advantage of all available technological innovations to improve survival, outcomes and recovery.
  • Primary, Adjunctive and Supportive Therapies – Evaluation of the effect of primary, adjunctive and supportive therapies, including immune modulators. Proposals will need to be placed in the context of work already underway in this area, including as listed in the WHO directory of clinical trials.
  • Vaccines - Evaluation of investigational vaccines and passive immunological approaches, improved collaboration and comparison across different studies. Proposals will need to robustly justify their case for funding, given significant existing international activity in this area.
  • Health and Care Delivery
    • Research which requires the real time pandemic context for delivery of the proposed study design.
    • Public health interventions to reduce the mortality and morbidity associated with COVID-19.
    • Evaluation of the care being delivered in hospitals and social care and the innovations in health and social care delivery prompted by the pandemic, which impact on the delivery of Covid19 care.
    • Evaluation of implementation, acceptability and feasibility of health and social care workforce interventions to support physical and mental health wellbeing.
    • Evaluation of different approaches to resource use and deployment of the workforce across the whole health and social care eco-system to deliver care for Covid19 patients and those suffering acute impacts from resulting changes in health and care delivery.
    • Research to support ensuring and optimising access to health and social care services, for example by people from different sociodemographic groups, ethnic groups and other groups who have the potential to have access issues. This may include those with communication needs that may not be being met in the current circumstances (due to lack of BSL interpretation or communication difficulties due to PPE etc) or inequalities around access to virtual care etc.

At this time this call is not designed to understand the wider long-term consequences of the delivery of health services in the context of a pandemic, or the impact of COVID-19 on delivery of services for other conditions

  • Underpinning
    • Assays and Animal Models - Development of assays and animal models required to support the development of therapeutics and vaccines. Proposals will need to be placed in the context of work already funded in this area.
    • Provision Infrastructure – Platforms supporting sharing of information, reagents, tools, protocols and standards. Proposals will need to be placed in the context of work already funded in this area.

Note: Rehabilitation after Covid-19 is an important area for research and it is suggested that researchers with rehabilitation proposals apply to NIHR’s Recovery and Learning Call.


Academic Principal Investigators applying for this call must be hosted by a UK institution which is eligible for UKRI funding. Applications from Small and Medium Enterprises[1] (including start-up or ‘spin-out’ companies), government arms length bodies, and NHS organisations (including NHS Trusts and NHS Foundation Trusts), and equivalent UK authorities are also encouraged in alignment with NIHR funding policies, where these organisations are the lead applicant.  Awards to UK-based, non-SME commercial entities will be also considered.  Specialist services or expertise may be brought into the team through consultancy or sub-contract arrangements, however, appropriate justification must be provided. Sub-contractors and collaborators (who are partners in the bid but not directly funded by it) may be based outside of the UK.

Researchers from overseas research organisations in affected countries providing important local engagement and context are welcomed as Co-Investigators on proposals. Other overseas researchers may be Co-Investigators, if they provide necessary expertise/access to resources not available in the UK.

Research institutes, including UKRI Units/Institutes, for which the Research Councils have established a long-term involvement as major funder are also eligible for this call.

Principal Investigators may only submit and have under review one application at a time to this rolling call as a Principal Investigator, but may be involved in more applications, if listed as a Co-Investigator. Applicants, whether as Principal or Co-Investigator, may not submit the same or similar application(s) as made to the Initiative’s first two calls or previously to this rolling call, or to the UKRI rolling call.


Studies should preferably build on existing relationships, including with relevant commercial, practice or policy partners and relevant data/resource holders. Interdisciplinary proposals are welcomed, where appropriate.

Proposals must be timely, with rapid activation, to enable early and valuable outcomes to be established and/or to access time-dependent resources.

Data produced as a result of this funding will need to be shared in line with the Joint statement on sharing research data and findings relevant to the novel coronavirus (nCoV) outbreak.

Funding available

The size of grants will vary according to the needs of each research project but will need to provide a robust case for value for money.

Requested costs for UK based researchers should be 80% of full economic costs (fEC) and, where relevant, for overseas researchers should be 100% of direct costs only. Funded projects in academia will be subject to standard UKRI T&Cs for fEC research grants. In line with NIHR funding policy this call will cover 100% direct costs for SME[1] and NHS trusts (across the whole of the UK). NIHR funding for NHS Trusts and SMEs, where they are the lead applicant, will be subject to a research contract which sets out a revenue sharing approach. An example contract for NHS trusts can be found here; an example contract for SMEs can be found here. Contractual terms for awards provided to UK-based, non-SME commercial entities will be agreed on a case-by-case basis between NIHR and the applicant.  There are no set rules on the split between collaborators, however, as the contracted organisation, the lead applicant will receive funding payments and would be required to distribute to co-applicants/contractors where applicable. Awards issued to NHS organisations through this initiative will be eligible for Research Capability Funding.

Applicants should provide costs of the proposal as set out in the application form. In Section 1.5 please provide the total request against each category, and provide a breakdown for 80% fEC and 100% costs in parentheses in the same field; the overall (top line) total request should be the sum of staff costs, travel, consumables and other directly incurred costs, and indirect, directly allocated and estates costs (the latter only applicable to fEC applications). A brief description of the resources required, including estimated costs, in the different contributing environments and confidence in access to these will need to be provided in Section 3.4. 


Proposals are anticipated to be short term studies of up to 12 months. All proposals will need to be able to show how progress within the period of award could make a valuable contribution to the understanding, diagnosis, prevention and/or management of the COVID-19 outbreak, with data and tools/reagents generated under this call to be made widely available.

How to apply

Applicants must apply by first filling out the information contained in the NIHR Clinical Research Network’s COVID-19 enquiry form.  At the end of this enquiry form, applicants will be provided with a link to a funding application form (Word document).  If you require funding you must complete a funding application after completing your enquiry form.  You do not need to wait for an outcome from your enquiry before submitting an application for funding. Please download and fill out the funding application form in full at your earliest convenience  Please contact us at ccf-nCoV@nihr.ac.uk regarding any issues related to access to this form.  Within this form, please use the tab key to move between cells.

All proposals must utilise the provided form and be accompanied by:

  • The regulatory requirements annex that forms part of the application form.
  • An optional but recommended document of supporting figures, GANTT chart and/or data tables (no more than 1xA4 page)
  • A CV for the Principal Investigator and any Co-Investigators. Each CV to provide relevant key publications/outputs and grants and other relevant information indicating their suitability to lead/support the research as described in the application (no more than 1xA4 page per CV using Arial 11 point).

Applications must be collated into a single pdf in the following order - Form plus Annex, Document of supporting figures, GANTT chart and/or data tables, CVs - and submitted to ccf-nCoV@nihr.ac.uk.

The office will not return applications due to missing data and/or components, with applicants bearing the risk of such missing data and/or components negatively impacting their proposal’s review.

Please note that successful applicants will be required to return their award acceptance within five working days of receipt, together with an invoice, from their Administering Authority. Failure to comply with these requirements could result in forfeiture of the award.

Award Start Date

Given that this opportunity is for timely proposals, grants are expected to start within four weeks of award notification.

Evaluation process

Proposals will be reviewed firstly by members of a college of experts, chosen based on the subject matter of the proposal. These reviews will then be used by an Expert Panel, who will make recommendations on outcome to UKRI and DHSC. Applicants will not have an opportunity to respond to Panel comments in instances where feedback is provided, except where clarifications and/or changes are required as part of the award process.

Key assessment criteria for the submissions will include:

  • The potential for the proposal to have an impact the within the period of the award and to provide a unique value-adding contribution relative to existing activity    
  • Access to required resources
  • Applicant expertise and experience
  • Partnership: including strength and clarity of collaborations and opportunities provided
  • Design and feasibility of project plan
  • Value for money
  • Alignment with WHO-Roadmap priorities

The decisions of the Panel will not be open to appeal and the funders reserve the right to amend the application process.

Ethics and governance

The funders do not require ethics permissions and regulatory approvals to be in place when an application is submitted. If an application is successful, it is the responsibility of the host institution/company to ensure that the appropriate ethics approval(s) has been obtained and that no research requiring such approval is initiated before it has been granted.

Contacts and guidance

For general and scientific queries relating to the call, including queries relating to the administrative process of applying, please contact ccf-nCoV@nihr.ac.uk

Other information

The information collected throughout the application and assessment process will be used to support the peer review process and inform our funding decisions, for the management and monitoring of awards, and the evaluation of the funding programme.

Proposal information is treated confidentially and in line with our privacy notice, UKRI fEC Grants Terms and Conditions and our guidance on the Use of Grant Proposal and Training Grant Information. Information relating to proposals may be shared, on a confidential basis, across DHSC and UKRI councils, and with other organisations to support the national and international coordination of research to combat COVID-19 and to seek funding contributions from third parties.

[1] SME is defined as registered in the UK, have a staff headcount no greater than 250 and annual turnover no greater than €50 million (including start-up or spin-out companies). Companies must be registered on Companies House prior to being eligible for funding.