Strategic investments and partnerships (IIB)
The Infections and Immunity Board (IIB) provides support to strategic Institutes, Units, Centres and resources.
- The Francis Crick Institute is a partnership with the Wellcome Trust, Cancer Research UK, Imperial College London, King’s College London and University College London. It is at the forefront of innovative biomedical research and promotes the translation of its research for maximal benefit.
- MRC Unit, The Gambia at London School of Hygiene and Tropical Medicine (LSHTM)
- MRC/UVRI and LSHTM Uganda Research Unit
- MRC Human Immunology Unit at the University of Oxford
- MRC-University of Glasgow Centre for Virus Research
- MRC Centre for Transplantation at King’s College London
- MRC Centre for Molecular Bacteriology and Infection at Imperial College London
- MRC Centre for Medical Mycology at University of Aberdeen
- MRC Centre for Global Infectious Diseases Analysis (formally the Centre for Outbreak Analysis and Modelling) at Imperial College London
- The MRC Consortium for Medical Microbial Bioinformatics, University of Warwick: Cyber-infrastructure for microbial bioinformatics; providing free cloud-based compute, storage, and analysis tools for academic microbiologists in the UK.
- STOP-HCV Stratified Medicine Consortium, University of Oxford: Aims to use patient information to establish the most effective and cost-effective treatments for patients with Hepatitis C Virus.
- Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine: Focused on designing rigorous epidemiological studies to identify and evaluate effective interventions against diseases of major public health importance in developing countries, and developing a cadre of leading LMIC epidemiologists.
IIB works with a large array of partners to prepare for and respond to infectious disease outbreaks and prosecute our immunology strategy. These include:
- DFID-Concordat: For more than two decades the MRC and the Department for International Development (DFID) have had a Concordat agreement in place to support a jointly funded portfolio of biomedical and public health research tackling the priority health problems of poor people in low- and middle-income countries (LMICs). Research themes for 2018-23 encompass priority areas in prevention and control of infections (HIV, tuberculosis (TB), malaria, emerging infections and neglected tropical diseases); maternal and neonatal health; health of women and children, girls and adolescents and other disadvantaged groups; non-communicable diseases; public health and health services.
- European and Developing Countries Clinical Trials Partnership (EDCTP): MRC is a member of, and chairs, this partnership, which aims to accelerate the development of new or improved drugs, vaccines, microbicides and diagnostics against HIV/AIDS, TB and malaria as well as other poverty-related infectious diseases in sub-Saharan Africa, with a focus on phase II and III clinical trials.
- The Joint Programming Initiative in Antimicrobial Resistance (JPIAMR): An EU-led initiative of global funders that support transnational research to combat AMR.
- GloPID-R: MRC is a member of this global alliance of research funding organisations, which aims to facilitate a rapid, effective research response in the event of an infectious disease outbreak.
- WHO Global Coordinating Mechanism for R&D for epidemic preparedness (GCM): The WHO Research and Development (R&D) Blueprint, of which the GCM is a part, is a global strategy and preparedness plan that aims to fast-track the availability of tests, vaccines and medicines to save lives and avert large scale crisis in pandemic outbreaks. It focuses on an annually reviewed set of priority diseases, for which there are no, or insufficient, countermeasures. It is generally agreed that preparedness and response, including the work of the Blueprint, would benefit from improved coordination and collaboration. The GCM is intended to fulfil this ambition for the Blueprint as well as other stakeholder-led initiatives. The MRC is a member, along with DFID and the Department of Health and Social Care (DHSC) from the UK.
- UK Vaccine Network (UKVN): Launched in 2015, the network brings together industry, academia and funders to make targeted investments (£120m over 2016-21) in specific vaccines and vaccine technology for infectious diseases with epidemic potential. Led by DHSC supported by MRC and the Biotechnology and Biological Sciences Research Council (BBSRC).
- Antimicrobial resistance (AMR) Initiative (£14.5m MRC, £88m total): The first initiative supported by all 7 research councils. It takes a multidisciplinary, themed approach to tackling the growing threat of antibacterial resistance.
- Zoonoses and Emerging Livestock Systems (ZELS): Cross Council £20.5m supported by DFID, BBSRC, Economic and Social Research Council (ESRC), MRC and Natural Environment Research Council (NERC).
- IIB’s portfolio of human infectious diseases research includes awards made through several of MRC’s international funding calls. We variously lead and support several Newton Fund and Global Challenges Research Fund (GCRF) initiatives, often in partnership with our sister councils. Both funds form part of the UK’s Official Development Assistance (ODA) commitment, which focuses on outcomes that promote the long-term sustainable growth of countries on the OECD Development Assistance Committee (DAC) list. Recent highlights include:
- UK-Vietnam Partnerships for Infectious Diseases Newton Call 2 (£2.75m total): A second call between MRC and the Vietnamese Ministry of Science and Technology.
- GCRF Infections Foundation Awards (£7.6m MRC, £10.9m total): Joint call with the Arts and Humanities Research Council (AHRC), BBSRC, ESRC and NERC. Supported 21 projects with potential to rapidly advance novel infectious disease Global Health discovery and translation research.
- GCRF Vector Borne Disease (VBD) Networks (£1.8m MRC, £5.3m total): BBSRC-led joint call with MRC and NERC, supported four interdisciplinary networks addressing challenges relating to VBD of plants, animals and humans.
- GCRF Vaccines R&D Networks (£6.4m MRC, £9.4m total): MRC-led joint call with BBSRC, established five collaborative networks in vaccine R&D targeting LMIC priority diseases integrating basic immunology and pathogen biology with vaccinology.