Stories about the people, science and research of the Medical Research Council.
3 May 2019
Recently, an international group of researchers met in Kolkata, India, for a workshop ran by the Global Network for Neglected Tropical Diseases. Here, Project Officer Mags Leighton explains how the network – and revolutionary gene editing technology – is creating new ways to tackle two neglected diseases.
Kolkata workshop attendees. Image copyright: Prof Nahid Ali.
Millions of people worldwide are infected by neglected tropical diseases (NTDs). The Global Burden of Disease Study 2017 revealed that just two of these – Chagas disease and leishmaniasis – together infect over 10 million people, causing an estimated 16,000 deaths and 321,000 ‘years lost to disability’. [...]
Continue reading: The gene editing workshops tackling invisible diseases
26 Apr 2019
This Sunday, thousands of marathon runners will be pounding the streets of London, raising vital money for charities across the UK. Many will be powering ground-breaking dementia research by fundraising for the UK Dementia Research Institute (UK DRI) through the Dementia Revolution campaign. The UK DRI is the single biggest investment in dementia research ever launched in the UK, set up by the MRC and charity founders Alzheimer’s Society and Alzheimer’s Research UK. Here, two runners with a very special connection to tackling dementia tell their story about what research means to them.
Carli Pirie – Study participant – UK DRI
I started taking part in research because my family have a genetic mutation that results in early-onset Alzheimer’s disease. We lost my nan very young and then started noticing signs in my mum.
When she was being diagnosed, I felt a little helpless and like I was out of control, so I signed up to the Dominantly Inherited Alzheimer’s Network (DIAN) study. I felt that by taking part, I could give something towards the future. [...]
Continue reading: Running for the Dementia Revolution
28 Mar 2019
First, we removed the time-bound criteria from our fellowship applications, to give people more time to apply after completing their PhD. Then we did the same for our New Investigator Research Grants (NIRG). Other funders have followed suit (including Wellcome and Cancer Research UK), and we know that many researchers have benefited from these changes. Here four new investigators and fellows describe the different paths they’ve followed to become independent researchers, and how broadening access to our schemes has helped them along the route. [...]
Continue reading: Beyond the sprint: stories from the marathon runners of science
14 Mar 2019
Could combining medical research with the arts help develop effective health interventions? Dr Cressida Bowyer, Senior Research Fellow in the Faculty of Creative and Cultural Industries at the University of Portsmouth, is figuring out how to combat harmful air pollution in a community in Sub-Saharan Africa using wonderfully creative means.
Mukuru river, Nairobi (Image copyright: Air Network).
Air pollution is a global issue, contributing to the ill health and premature death of millions of people. Health impacts are vast, including chronic lung disease in adults and pneumonia in children. Those living in poor urban environments are especially likely to be exposed to dangerous levels of air pollution, with nine out of 10 related deaths occurring in low and middle-income countries. [...]
Continue reading: Using music as a force for change
15 Feb 2019
Last month, MRC Protein Phosphorylation and Ubiquitylation Unit scientists hosted a lab tour for people affected by Parkinson’s disease. Clinical Programme Leader Dr Esther Sammler, also an honorary consultant neurologist at NHS Tayside, explains why listening to the experiences of people living with the disease is so important for research.
MRC scientists (front row: author Dr Esther Sammler fifth from left, Professor Miratul Muqit third from left; back row: Director Professor Dario Alessi left, Paul Davies right) with Dundee Research Interest Group steering committee members (front row: Group Chair Marc van Grieken far left, Secretary Werner Remmele fourth from left).
Parkinson’s disease is a common condition in which parts of the brain become progressively damaged over many years. Most people are familiar with the physical signs of the disease, such as slowness of movement, stiffness and limb shaking. But other symptoms – that are just as troubling – include sleep and mood problems, loss of smell, and declining memory skills. In Scotland alone, there are 12,000 people living with the condition. [...]
Continue reading: Making Parkinson’s disease research personal
24 Jan 2019
Computational scientist Stephen Taylor and his team at the MRC Weatherall Institute of Molecular Medicine (MRC WIMM) are helping scientists and surgeons explore biological structures up closer than ever before. He takes us on a tour of his virtual reality vision.
Credit: Martin Phelps
If you’re an engineer looking to fix a problem in the network of tunnels in the London Underground, you wouldn’t find the standard 2D London Tube map much use. [...]
Continue reading: Virtual reality in research
17 Jan 2019
Many of us enjoy raising a glass when we celebrate, socialise or relax after work. But do you know, or even think, about what’s inside? According to Senior Research Associate Dr Anna Blackwell, probably not. Now that alcohol misuse is the biggest risk factor for ill health, disability and early death for 15 to 49-year-olds in England, Anna tells us why this needs to change.
There are carefully crafted cues all around you that influence your behaviour. Many of these come from industry, like the two-for-one deals or pretty bottles that make you more likely to choose one drink over another. Or the nice sofas and cosy atmosphere that might encourage you to stay longer in a bar then you’d planned. [...]
Continue reading: How can we help drinkers make healthier choices?
9 Jan 2019
This festive season, stem cell scientist Professor Bobby Gaspar, from the UCL Great Ormond Street Institute of Child Health, appeared as a special guest on the BBC Royal Institution Christmas Lectures. Here he shares the thrill of healing patients using gene therapy – and why it’s so important to communicate the science behind new medicines to the world.
Professor Aoife McLysaght, gene therapy patient Rhys & Professor Bobby Gaspar. Image: Paul Wilkinson Photography
To be a part of the Christmas Lectures alongside Rhys, the first patient to be successfully treated at Great Ormond Street Hospital with gene therapy back in 2001, was very special. [...]
Continue reading: Sharing the science of gene therapy
11 Dec 2018
In India, more than 75% of people experiencing mental illness have no access to mental healthcare. Working with the Sangath organisation in Goa, Research Assistant Alison Garber explains how she’s hoping to provide healthcare from a distance for people in rural communities.
Meet Priya*, a 25-year-old woman who lives in a remote village in Goa, India. Ever since her adolescence, she’s been experiencing severe mental health issues that deeply affect her family. She breaks objects at home and hurts herself by hitting her hands and legs repeatedly. The family have travelled great distances seeking help, but with no success. They are growing increasingly desperate. [...]
Continue reading: Connecting urban psychiatry with rural India
7 Dec 2018
A team in Edinburgh is conducting vital research into how to improve the lives of more than 170 million women globally affected by endometriosis, a debilitating condition that often goes undiagnosed. Here, project co-director and principal investigator at the MRC Centre for Reproductive Health, Professor Andrew Horne, explains how a £100,000 donation from the Charles Wolfson Charitable Trust will support their vital research into the condition.
While 80 per cent of adults are familiar with diabetes, fewer than 20 per cent have heard of endometriosis. That startling figure, provided by Endometriosis.org, emphasises one of the reasons why it is such a difficult condition to research, and why developing better management and treatment remains a challenge.
Andrew Horne and his research team are conducting vital research into endometriosis, part funded by a
£100,000 donation from the Charles Wolfson Charitable Trust [...]
Continue reading: Hidden suffering