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Insight blog: Posts tagged with ribosome

Stories about the people, science and research of the Medical Research Council.

Behind the picture: An early model of the ribosome

12 Mar 2014

The MRC National Institute for Medical Research (NIMR) turns 100 this year and its rich history is fertile ground for looking back on past discoveries. This 1960s molecular model represents an important point in the evolution of thinking about the structure of the ribosome. Katherine Nightingale spoke to Dr Bob Cox about constructing the model ― and getting a few giants of biomedical research to sign it too. 

Bob Cox's ribosome model, with Crick's signature second from right on the top row

Bob Cox’s ribosome model, with Crick’s signature second from right on the top row

Look closely at one of these polystyrene balls and you’ll find the autograph of one of science’s most celebrated sons, Francis Crick. As well as being part of the duo that discovered the structure of DNA, Crick also proposed the “central dogma” of molecular biology: that DNA makes RNA makes protein. Fitting then, that his signature is here on an early model of the ribosome, the molecular machine that makes proteins.

Ribosomes are cellular factories made of RNA and protein which ‘translate’ the genetic code into the corresponding amino acid code, specific to each protein. They are large and complex molecules, made up of around 50 proteins divided into two subunits. They were discovered in 1955, though they didn’t get their name until 1958.

This model, produced by NIMR researcher Bob Cox in 1969, was the first attempt to model ribosome structure in detail. Until then, only blurry microscope pictures had been available. [...]

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