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Breakthrough Generations Study

About the cohort

PI: Professor Andrew Swerdlow and Professor Alan Ashworth

Start date: 2004
Age at recruitment: >16
Sample size at recruitment: 112,798
Estimated current sample size:110,000

The study involves over 110,000 women recruited between 2004-2009 from the general population from whom information has been gathered about factors that might relate to breast cancer risk or protection. Contact is then being kept with these women over time to determine their risks of breast cancer in relation to these factors.

The Breakthrough Generations Study has been designed to investigate the complex interplay of lifestyle, environmental, genetic and hormonal factors acting throughout a woman’s life and determine how these affect an individual’s risk of developing breast cancer. Pinpointing these factors should be of benefit to present and future generations, and enable women to make informed lifestyle choices.


Breakthrough Breast Cancer


Page last updated: 3 Aug 2004


  • Gender: Female
  • Sample size: 100,000-499,999
  • Age: 10 to 19, 20 to 39, 40 to 59, 60 to 100
  • Anthropometric: Height, Weight, Waist circumference, Hip circumference
  • Physical: Musculoskeletal, Hearing and vision, Reproductive
  • Lifestyle: Smoking, Physical activity, Dietary habits, Alcohol
  • Socio-economic: Occupation, Family circumstances, Education, Ethnic group, Marital status
  • Biological samples: Blood, Urine