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East London Genes & Health

About the cohort

Start date: April 2015
Age at recruitment: 16+
Current sample size: 33,000 (Nov 2018)
Sample size estimated end of 2019: 50,000
Sample size estimated end of 2023: 100,000
For up to date sample size, please see the Genes & Health website.

East London Genes & Health (ELGH) is a large-scale, community genomics and health study (to date >30,000 volunteers; target 100,000 volunteers).

ELGH was set up in 2015 to gain deeper understanding of health and disease, and underlying genetic influences, in people of British-Bangladeshi and Pakistani heritage living in east London.

ELGH prioritises studies in areas important to, and identified by, the community it represents. Current priorities include cardiometabolic diseases and mental illness, these being of notably high prevalence and severity. However studies in any scientific area are possible, subject to community advisory group and ethical approval.

ELGH combines health data science (using linked UK National Health Service (NHS) electronic health record data) with exome sequencing and SNP array genotyping to elucidate the genetic influence on health and disease, including the contribution from high rates of parental relatedness on rare genetic variation and homozygosity (autozygosity), in two understudied ethnic groups. Linkage to longitudinal health record data enables both retrospective and prospective analyses.

Through stage 2 studies, ELGH offers researchers the opportunity to undertake recall-by-genotype and/or recall-by-phenotype studies on volunteers. Sub-cohort, trial-within-cohort, and other study designs are possible.

ELGH is a fully collaborative, open access resource, open to academic and life sciences industry scientific research partners.

Core funders

Wellcome Trust

Contact

Cohort profile: https://www.biorxiv.org/content/early/2018/09/27/426163

Website: www.genesandhealth.org

Email: elgh@qmul.ac.uk

Page last updated: 29 Nov 2018

Categories

  • Gender: Male, Female
  • Sample size: 20,000-49,999
  • Age: 10 to 19, 20 to 39, 40 to 59, 60 to 100
  • Anthropometric: Height, Weight, Blood pressure
  • Physical: Cardiovascular, Respiratory, Musculoskeletal, Hearing and vision, Reproductive
  • Psychological: Mental health, Cognitive function
  • Lifestyle: Smoking, Physical activity, Dietary habits, Alcohol
  • Socio-economic: Ethnic group
  • Biological samples: Blood, Saliva