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Joint Global Health Trials

Joint Global Health Trials

Launched in 2010, the Joint Global Health Trials (JGHT) scheme provides funding for research to generate new knowledge about interventions that will contribute to the improvement of health in low- and middle-income countries and is jointly funded by the Foreign, Commonwealth and Development Office (FCDO), the MRC, the National Institute for Health Research (NIHR) and Wellcome. The partner agencies share the view that in order to have maximum impact on health we need to work together to provide evidence of the best, and most appropriate interventions

The purpose of this scheme is to fund rigorous research to produce implementable evidence addressing questions of major importance to mortality and morbidity in low- and middle-income countries.  The scheme primarily funds RCTs, but innovative trial methodologies and adaptive designs are also welcome. The scheme focuses on late-stage (equivalent to phase III/IV) clinical and health intervention trials that evaluate efficacy and effectiveness but we may also consider phase IIb stage trials if they are of major relevance to the objectives of the call.

The scheme is open to proposals for any major health related problem affecting low- and middle-income countries, particularly those that affect the most vulnerable populations.  Although the breadth of the scheme is deliberately wide, we particularly welcome proposals for research into chronic non-communicable diseases, including mental health reproductive, maternal and new born health.

The joint funders have run ten successful calls for this scheme and have secured funding for the current 11th call. Applications can be submitted from both UK- and LMIC-led research teams.

After 7 funding calls were complete, the joint funders commissioned an independent review of the scheme to understand the impact of JGHT funding and to determine if it was delivering its core aims. The evidence reviewed demonstrated that JGHT is delivering on its core aim and has achieved tangible outcomes and impacts: JGHT-funded research has generated new knowledge about interventions which in turn are starting to contribute to improving health in LMICs. The full report can be found here:

Previous joint global health trials calls

Joint Global Health Trials scheme - call 4

Joint Global Health Trials scheme – call 5

Joint Global Health Trials scheme – call 6

Joint Global Health Trials scheme – call 7

Joint Global Health Trials scheme - call 8

Joint Global Health Trials scheme - call 9

Joint Global Health Trials scheme - call 10

Joint Global Health Trials scheme - call 11


All initial enquiries should be directed to the Medical Research Council: JGHT@mrc.ukri.org