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Multimillion pound grants bring UK and Chinese researchers together in the global fight against superbugs

28 Nov 2018

According to the Jim O’Neill Review on Antimicrobial Resistance, China uses around half the antibiotics consumed worldwide. Of these, 48% are consumed by humans and the rest is used in food-producing animals. The report suggests that AMR could cause a million premature deaths per year by 2050 in China alone.

To address this, an £8 million investment by the UKRI AMR Cross Council Initiative through the Newton Fund and 36 million RMB from the National Natural Science Foundation of China (NSFC) will support new interdisciplinary China-UK AMR partnership hubs.

The four winning collaborations, with teams led by the University of Warwick and the Chinese Academy of Sciences; the University of Bristol and Peking University Health Science Centre; Cardiff University and China Agricultural University; and the University of Birmingham and Zhejiang University, bring together leading researchers from both countries to explore and address factors behind the rise in antibacterial resistance in China.

This interdisciplinary approach will enable researchers to:

  • investigate in detail the emergence and spread of resistant bacteria
  • understand the impact this has on the environment, agricultural systems, animals and humans using a 'one health' approach
  • develop new interventions, including new drugs
  • support policymakers to improve health and agricultural systems.

The new collaborations will build on the success of the 2016 China-UK AMR Partnership Initiative whose research provided supporting evidence for the Chinese government’s internationally recognised ban of colistin, an antibiotic of last resort, from animal use.

Dr Jonathan Pearce, Head of Infections and Immunity at the MRC, said: “Resistance to antibiotics is a growing problem that does not respect national borders. We are facing an alarming rise in the number of bacteria becoming resistant to existing antibiotics without an increase in new antibiotics or new treatments.

“The upsurge in resistance is driven by a complex interplay of biomedical, animal, social, cultural and environmental factors and so an international and interdisciplinary approach like this is vital if we are to stop it in its tracks.”

Professor Fan Yingjie, Deputy Director-General of NSFC Bureau of International Cooperation, said: “NSFC has been building research links between China and UK for years and the launch of the four interdisciplinary research projects is a new evidence of the strong collaborative relationship between NSFC and UKRI. Combining the expertise and resources of both China and the UK has proven very successful in producing innovative and impactful results. I look forward to seeing the outcomes from today’s successful applicants.”

The four grants have been allocated to the following UK principal investigators who will each work closely with a Chinese counterpart.

UK grant holder

UK research organisation

Chinese grant holder

Chinese research organisation

Proposal title

Professor Christopher Dowson

University of Warwick

Professor Jian Min Yue

Chinese Academy of Sciences

CHNUK: Integrated platforms from science to policy in response to antibacterial resistance

Professor Helen Lambert

University of Bristol

Professor Bo Zheng

Peking University Health Science Centre

Strategies to reduce the burden of antibiotic resistance in China

Dr Alan McNally

University of Birmingham

Professor Yunsong Yu

Zhejiang University

DETECTIVE: Dissemination and resistance mechanisms of carbapenem-resistant Gram-negative bacilli

Professor Timothy Walsh

Cardiff University

Dr Yang Wang

China Agricultural University

Determining the clinical and environmental impact, burden and cost of Extensively Drug Resistant Enterobacteriaceae in China (DETER-XDRE-CHINA-HUB)

 

Together with our UKRI partners, we are sponsoring a Science Museum exhibition, putting the spotlight on antibiotic resistance, running until spring 2019.

Read more about AMR on the MRC website.

Categories

  • Categories: Funding
  • Health categories: Infection
  • Strategic objectives: Environment and health, International partnerships and shaping the agenda, Global health, Aim: Picking research that delivers, Aim: Research to people, Aim: Going global
  • Locations: Other
  • Type: News article