About the UK Brain Banks Network
What is the UK Brain Bank Network?
The UK Brain Banks Network is an initiative, led by the MRC, to establish a coordinated national network of UK brain tissue resources (banks) for researchers to use.
The banks store post-mortem brain and central nervous system (CNS) tissue donated by the public for diagnosis and research into disorders. Advances in understanding genetics and many of the molecules that define brain function mean that more and more research questions can be answered from human brain tissue.
The UK Brain Banks Network supplies tissue samples to academic and industry researchers in the UK and abroad. All brain banks in the Network have approval to provide tissue samples to research projects and pilot studies. Approval is based on scientific merit and takes into account ethical issues (if peer review and ethics approval has not yet been obtained).
The banks work together to agree common standards of operation and to harmonise protocols for consent, tissue handling and storage, quality indicators and the application process for access to tissue samples.
Brain banks in the Network are distributed across the country and donors register with the brain bank nearest to them. Researchers can apply to use tissue from any bank, some of which specialise in different disease areas, for example: dementia, multiple sclerosis, Parkinson’s and autism.
An important early aim of the Network was to improve the supply of ‘healthy’ tissue that can be used in scientific studies as a control (or comparison) for tissue samples from patients with neurological disease.
To help achieve this, the MRC now funds two brain banks that focus on the collection of control tissue samples: the Sudden Death Brain and Tissue Bank at the University of Edinburgh and the Thomas Willis Brain Collection at the Oxford Biomedical Research Centre. Many samples of normal tissue are requested by researchers across the UK for a range of projects including large-scale genetic investigations into neurological diseases.
None of the banks in the UK Brain Bank Network collect foetal brains, however the banks do communicate with other resources, such as the MRC/Wellcome Trust Human Developmental Biology Resource, which collect voluntary donations of embryonic/fetal material.
Funding of the UK Brain Bank Network
Each bank receives funding from a variety of different sponsors e.g. the MRC, NHS Trusts, and UK-wide and smaller charities. The five UK charities supporting the Network are:
- Alzheimer’s Research UK
- Alzheimer’s Society
- Multiple Sclerosis Society
- Parkinson’s UK
The Steering Committee has oversight of the UK Brain Banks Network and provides scientific and strategic advice to the Director. It meets face-to-face twice yearly.
Members have expertise in a number of areas related to the Network’s activities including: neuroscience and epidemiology; ethics and law; brain and tissue banking in the UK and Europe; and non-professional representation. Meetings are attended by observers from different charities, industry, the Human Tissue Authority and NC3Rs.
Terms of Reference:
- To provide advice to the Director on the development of the UK Network of Brain Banks and to support him in achieving the goals of the Network.
- To ensure that strategies are in place to manage risk.
- To monitor implementation of the Network to ensure that:
- A code of practice is developed for all aspects of how the Network should operate.
- The manner of operation takes into account the interests of potential donors, their families and the wider public.
- The manner of operation takes account of the scientific needs of users (for example in the manner of freezing, storage and phenotyping, to enable DNA-based studies, proteomics and expression profiling).
- Protocols for brain banking align well with protocols for relevant clinical and other cohort studies and allow comparison with animal studies.
- The Network collects and makes available control brains and other brain material that is in short supply (psychiatric disorders, rare conditions etc.).
- A robust communications strategy is implemented.
- To consider issues identified by the Scientific User and Management Groups or any other part of the network.
- To receive regular reports on applications to deposit and access brain tissue from the network.
- To receive regular reports on the activities of the Network, including liaison with the relevant authorities (NIHR, devolved administrations, HTA, National Blood and Transplant, etc.).
- To report at least annually to the MRC and to provide an annual public report of activity.
- To review the membership and terms of reference of the Committee annually.
Professor Hugh Perry (University of Southampton)
- Professor Herbert Budka (Medical University of Vienna)
- Professor Cathie Sudlow (UK Biobank, University of Edinburgh)
- Professor Maria Grazia Spillantini (University of Cambridge)
- Professor James Nicoll (BRAIN UK, University of Southampton)
- Dr Zeshan Ahmed (Lilly UK)
- Dr Susan Wallace (University of Leicester)
- Partner charities (Alzheimer’s Research UK, Alzheimer’s Society, Autistica, Multiple Sclerosis Society, Parkinson’s UK)
- Dr Anthony Holmes (NC3Rs)
- Dr Ali Hansford (Association of the British Pharmaceutical Industry)
- Dr Christopher Birkett (Human Tissue Authority)
- Ms Anna Myers (Dementias Platform UK)
- Professor Paul Francis (Brains for Dementia Research)
The Network Management Group has responsibility for the running of the network. The group is made up of the network Director, the principal investigators for each of the brain banks and a lay member. It meets twice yearly.
The Group agrees policy for dealing with requests, standard operating procedures, data sharing and the network’s tissue database, sample acquisition and storage. The Group keeps abreast of operational and technical developments and updates/advises the Steering Committee accordingly.
The Management Group and the Steering Committee have developed a framework to ensure that the network operates within the relevant human tissue and data protection legislation; research governance; GMC probity; ethical guidelines and health and safety guidelines. Sub-working groups are set-up to work through specific issues problems as they arise.
Professor Seth Love (Director of the Network, University of Bristol)
- Dr Kieren Allinson (Cambridge Brain Bank)
- Professor Safa Al-Sarraj (MRC London Neurodegenerative Diseases Brain Bank)
- Professor Olaf Ansorge (Thomas Willis Brain Collection)
- Professor Johannes Attems (Newcastle Brain Tissue Resource)
- Dr Zane Jaunmuktane (Queens Square Brain Bank for Neurological Disorders)
- Dr Robin Highley (Sheffield Brain Tissue Bank)
- Professor Federico Roncaroli (Manchester Brain Bank)
- Professor Richard Nicholas (Multiple Sclerosis Society Tissue Bank)
- Professor Steve Gentleman (Parkinson’s UK Brain Bank)
- Professor Colin Smith (MRC Brain and Tissue Banks in Edinburgh)
- Archbishop Douglas Lewins (Lay member)
In the next 12 months, activities will focus on the following:
- Increased communication activities and engaging new researchers
- Improving the database
- Implementing the cost recovery model
- Working with the Dementias Platform UK to develop policies which align with the Brain Banks Network and implement the consenting of identified cohorts
- Identifying new opportunities/priority areas for brain donation/data capture